Ret^tm2(RET)Jmi
Targeted Allele Detail

Summary

• Symbol: Ret^tm2(RET)Jmi
• Name: ret proto-oncogene; targeted mutation 2, Jeffrey Milbrandt
• MGI ID: MGI:3057332
• Synonyms: Ret⁹, Ret^RET9
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm2(RET)Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ret^tm2(RET)Jmi expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: Human RET9 cDNA and a floxed neo were inserted into exon 1 of the endogenous locus. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain. (J:93262)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:93262 Jain S, et al., Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development. 2004 Dec;131(21):5503-13
• All: 9 reference(s)