Maoa^K284stop
Spontaneous Allele Detail

Summary

• Symbol: Maoa^K284stop
• Name: monoamine oxidase A; K284stop
• MGI ID: MGI:3057337
• Synonyms: Maoa^A863T, MAO A KO
• Gene: Maoa Location: ChrX:16485937-16554051 bp, + strand Genetic Position: ChrX, 11.78 cM, cytoband A2
• Alliance: Maoa^K284stop page

Mutation origin

• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• An A-to-T at coding nucleotide 850 in exon 8 created a stop codon at lysine codon 284 (p.K284*). (J:93356, J:136818)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Maoa Mutation: 11 strains or lines available

References

• Original: J:93356 Chen K, et al., A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem. 2004 Oct 17;279(38):39645-52
• All: 11 reference(s)