Tg(RIP1-Neurod1)1Jle
Transgene Detail

Summary

• Symbol: Tg(RIP1-Neurod1)1Jle
• Name: transgene insertion 1, Jacqueline E Lee
• MGI ID: MGI:3487269
• Synonyms: RIP1-ND
• Transgene: Tg(RIP1-Neurod1)1Jle Location: unknown
• Alliance: Tg(RIP1-Neurod1)1Jle page

Transgene origin

• Strain of Origin: 129S4/SvJaeSor and C57BL/6 and CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RIP1-Neurod1)1Jle expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Neurod1 (MGI:1339708)

• Mutation details: The transgene contains ~700-bp of the rat insulin promoter (RIP-1) and a 1.8-kb mouse Neurod1 coding region with its amino terminus fused to a Myc tag. The rat insulin promoter is used to drive the transgene expression in pancreatic islets. Transgene expression, as shown by immunostaining using anti-Myc tag antibody, is detected in the pancreatic islets but not in the brains of P30 rescued mice. (J:74715)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:74715 Miyata T, et al., NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52
• All: 2 reference(s)