Del(16Cbr1-Fam3b)1Rhr
Targeted Allele Detail

Summary

• Symbol: Del(16Cbr1-Fam3b)1Rhr
• Name: deletion, Chr 16, R H Reeves 1; deletion, chr 16, R H Reeves 1
• MGI ID: MGI:3487281
• Synonyms: Del1Rhr, Ms1Rhr
• Gene: Del(16Cbr1-Fam3b)1Rhr Location: Chr16:93404725-97306136 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93223
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Mutation details: Deletion of a 3.9 Mb segment of Chr 16 was engineered by cre-mediated recombination between single loxP sites inserted into homologous chromosomes. This deleted segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human Down syndrome critical region. (J:93223)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16Cbr1-Fam3b)1Rhr Mutation: 1 strain or line available

Notes

A line of mice with segmental monosomy for Chr 16 was derived from descendants of the chimeric founder.

References

• Original: J:93223 Olson LE, et al., A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science. 2004 Oct 22;306(5696):687-90
• All: 7 reference(s)