Dp(16Cbr1-Fam3b)1Rhr
Targeted Allele Detail

Summary

• Symbol: Dp(16Cbr1-Fam3b)1Rhr
• Name: duplication, Chr 16, R H Reeves 1
• MGI ID: MGI:3487283
• Synonyms: Dp(16Cbr1-ORF9)1Rhr, Ts1Rhr
• Gene: Dp(16Cbr1-Fam3b)1Rhr Location: Chr16:93404725-97306136 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93223
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Duplication
• Dp(16Cbr1-Fam3b)1Rhr involves 68 genes/genome features (Gm22344, Gm15341, Gm15317 ...) View all
• Mutation details: A duplication of a 3.9 Mb region on chromosome 16 was engineered by Cre-mediated recombination between inserted loxP sites located on different chromosomes. This duplicated segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human Down syndrome critical region. (J:93223)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(16Cbr1-Fam3b)1Rhr Mutation: 1 strain or line available

References

• Original: J:93223 Olson LE, et al., A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science. 2004 Oct 22;306(5696):687-90
• All: 31 reference(s)