Gata3^tm1Jfz
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1Jfz
• Name: GATA binding protein 3; targeted mutation 1, Jinfang Zhu
• MGI ID: MGI:3487291
• Synonyms: Gata^fl
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1Jfz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93538
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Homologous recombination was used to flox exon 4, which encodes part of the zinc fingers important for DNA binding. Crossing with mice expressing Cre in the germ line excised a floxed neo from the inserted targeting construct. (J:93538)

Expression

In Mice Carrying this Mutation:	38 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 32 strains or lines available

References

• Original: J:93538 Zhu J, et al., Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol. 2004 Nov;5(11):1157-65
• All: 42 reference(s)