Tg(Tnfrsf4-cre)1Nik
Transgene Detail

Summary

• Symbol: Tg(Tnfrsf4-cre)1Nik
• Name: transgene insertion 1, Nigel Killeen
• MGI ID: MGI:3487294
• Synonyms: OX40-cre
• Transgene: Tg(Tnfrsf4-cre)1Nik Location: unknown
• Alliance: Tg(Tnfrsf4-cre)1Nik page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tnfrsf4-cre)1Nik expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tnfrsf4

• An IRES-cre sequence was placed into the Tnfrsf4 locus. (J:93538)

Recombinase activity

Activity:	Tissue activity of this recombinase allele MGI has not yet included tissue activity data for this allele in any anatomical systems.
Driver:	Tnfrsf4 (species not specified) Summary of all recombinase alleles driven by Tnfrsf4.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Gt(ROSA)26Sor^tm1(DTA)Kio/Gt(ROSA)26Sor^+ Tg(Tnfrsf4-cre)1Nik/0	B6.129-Tnfrsf4^tm2(cre)Nik Gt(ROSA)26Sor^tm1(DTA)Kio
cn2	Gata3^tm1Jfz/Gata3^tm1Jfz Tg(Tnfrsf4-cre)1Nik/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	cn1	cn2
show or hide all annotated terms
digestive/alimentary system	√
exocrine pancreas atrophy	√
endocrine/exocrine glands	√
exocrine pancreas atrophy	√
growth/size/body	√
decreased body size	√
postnatal growth retardation	√
hematopoietic system		√
abnormal CD4-positive, alpha beta T cell morphology		√
increased T-helper 1 cell number		√
decreased T-helper 2 cell number		√
decreased IgE level		√
immune system		√
abnormal CD4-positive, alpha beta T cell morphology		√
increased T-helper 1 cell number		√
decreased T-helper 2 cell number		√
decreased IgE level		√
increased susceptibility to parasitic infection		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93538 Zhu J, et al., Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol. 2004 Nov;5(11):1157-65
• All: 9 reference(s)