Sncb^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Sncb^tm1.1Sud
• Name: synuclein, beta; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:3487297
• Synonyms: beta^-, BSR
• Gene: Sncb Location: Chr13:54906673-54914408 bp, - strand Genetic Position: Chr13, 29.28 cM
• Alliance: Sncb^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93544
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sncb^tm1Sud mice were crossed with mice expressing cre in the germline, thereby removing floxed exon 2, which encodes amino acids 1-41. (J:93544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sncb Mutation: 18 strains or lines available

References

• Original: J:93544 Chandra S, et al., Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14966-71
• All: 16 reference(s)