Hipk2^tm1Ejh
Targeted Allele Detail

Summary

• Symbol: Hipk2^tm1Ejh
• Name: homeodomain interacting protein kinase 2; targeted mutation 1, Eric J Huang
• MGI ID: MGI:3487301
• Gene: Hipk2 Location: Chr6:38671325-38853099 bp, - strand Genetic Position: Chr6, 17.85 cM, cytoband B
• Alliance: Hipk2^tm1Ejh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ and PGK-neo replaced exon 3 (the first coding exon) and were inserted in frame with the first ATG via homologous recombination. Northern analysis and RT-PCR confirmed the absence of mRNA in MEFs and trigeminal ganglia, respectively. Beta-galactosidase was expressed in developing trigeminal ganglion and dorsal root ganglion. (J:93311)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hipk2 Mutation: 55 strains or lines available

References

• Original: J:93311 Wiggins AK, et al., Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol. 2004 Nov 25;167(2):257-67
• All: 12 reference(s)