Pax7^tm1(cre)Mrc
Targeted Allele Detail

Summary

• Symbol: Pax7^tm1(cre)Mrc
• Name: paired box 7; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:3497712
• Synonyms: Pax7-cre, Pax7^Cre, Pax7-ICN^Cre, Pax7^ICNm
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^tm1(cre)Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93443
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pax7^tm1(cre)Mrc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax7 (MGI:97491)

• Mutation details: An IRES-Cre-FRT-neo-FRT cassette was inserted into the 3' UTR following the stop codon in exon 10. Crossing with mice expressing FLP-e excised the neo. The insertion did not interfere with normal Pax7 function. (J:93443)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax7 (mouse) Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities Alliance mouse Pax7 gene page

Expression

In Mice Carrying this Mutation:

39 assay results 5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 38 strains or lines available

References

• Original: J:93443 Keller C, et al., Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004 Dec 1;18(21):2608-13
• All: 82 reference(s)