Dmbt1^tm1Qaa
Targeted Allele Detail

Summary

• Symbol: Dmbt1^tm1Qaa
• Name: deleted in malignant brain tumors 1; targeted mutation 1, Qais Al-Awqati
• MGI ID: MGI:3497714
• Gene: Dmbt1 Location: Chr7:130633787-130723357 bp, + strand Genetic Position: Chr7, 73.2 cM, cytoband F4
• Alliance: Dmbt1^tm1Qaa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93477
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ and a PGK-neo cassette replaced the first exon encoding the signal peptide via homologous recombination. Beta-galactosidase expression was first detected in the E3.5 inner cell mass. (J:93477)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmbt1 Mutation: 111 strains or lines available

References

• Original: J:93477 Takito J, et al., Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin. J Cell Biol. 2004 Oct 27;166(7):1093-102
• All: 1 reference(s)