Ddit4^tm1Fein
Targeted Allele Detail

Summary

• Symbol: Ddit4^tm1Fein
• Name: DNA-damage-inducible transcript 4; targeted mutation 1, Elena Feinstein
• MGI ID: MGI:3497720
• Synonyms: RTP801^-
• Gene: Ddit4 Location: Chr10:59785497-59787592 bp, - strand Genetic Position: Chr10, 29.66 cM, cytoband B3
• Alliance: Ddit4^tm1Fein page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93450
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LacZ and a PGK-neo cassette replaced a 212-bp region encompassing exon 2, the first coding exon, via homologous recombination. Northern blot analysis confirmed absence of protein in various tissues. (J:93450)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddit4 Mutation: 18 strains or lines available

References

• Original: J:93450 Brafman A, et al., Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Invest Ophthalmol Vis Sci. 2004 Nov;45(10):3796-805
• All: 26 reference(s)