Dnmt1^{tm1(tetO-BCL2)Sjk}
Targeted Allele Detail

Summary

• Symbol: Dnmt1^{tm1(tetO-BCL2)Sjk}
• Name: DNA methyltransferase 1; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:3497721
• Synonyms: Dnmt1^tm1Sjk, tet-BCL-2
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^{tm1(tetO-BCL2)Sjk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Dnmt1^{tm1(tetO-BCL2)Sjk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: A targeting vector containing human BCL2 under the control of tet operator sequences and a minimal CMV promoter was inserted into the endogenous locus. (J:93549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 112 strains or lines available

References

• Original: J:93549 Letai A, et al., Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell. 2004 Sep;6(3):241-9
• All: 2 reference(s)