Hgfac^tm1Hk
Targeted Allele Detail

Summary

• Symbol: Hgfac^tm1Hk
• Name: hepatocyte growth factor activator; targeted mutation 1, Hiroaki Kataoka
• MGI ID: MGI:3497731
• Synonyms: HGFA^-
• Gene: Hgfac Location: Chr5:35198853-35205805 bp, + strand Genetic Position: Chr5, 17.99 cM
• Alliance: Hgfac^tm1Hk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93428
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a neomycin resistance gene by homologous recombination. RT-PCR, Northern blot and Western blot analyses confirmed absence of transcript and protein in mutant livers and colons. (J:93428)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgfac Mutation: 27 strains or lines available

References

• Original: J:93428 Itoh H, et al., Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Gastroenterology. 2004 Dec;127(5):1423-35
• All: 3 reference(s)