Plod3^tm1Soin
Targeted Allele Detail

Summary

• Symbol: Plod3^tm1Soin
• Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; targeted mutation 1, Raija Soininen
• MGI ID: MGI:3497741
• Synonyms: Plod3^-
• Gene: Plod3 Location: Chr5:137015873-137025500 bp, + strand Genetic Position: Chr5, 76.09 cM
• Alliance: Plod3^tm1Soin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93434
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A LacZ-PGK-neo cassette was inserted into exon 1 via homologous recombination. Northern analysis using the 3' end as a probe detected a faint band that when analyzed was found to be a nonfunctional transcript. This aberrant transcript contains a long stretch of antisense PGK, part of intron 2 and downstream exons. Beta-galactosidase was expressed under the control of the endogenous promoter. (J:93434)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plod3 Mutation: 60 strains or lines available

References

• Original: J:93434 Rautavuoma K, et al., Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14120-5
• All: 2 reference(s)