Myb^tm1Epr
Targeted Allele Detail

Summary

• Symbol: Myb^tm1Epr
• Name: myeloblastosis oncogene; targeted mutation 1, E Premkumar Reddy
• MGI ID: MGI:3497746
• Synonyms: myb^F
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^tm1Epr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93481
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6 encoding the high-affinity DNA-binding domain was flanked with loxP sites by homologous recombination of a construct that also contained a PGK-neo and thymidine kinase selection markers. The PGK-neo-thymidine kinase marker was excised by transient transfection of properly targeted ES cells with a cre-expressing plasmid and left exon 6 flanked by loxP sites. (J:93481)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 53 strains or lines available

References

• Original: J:93481 Lieu YK, et al., Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A. 2004 Nov 12;101(41):14853-8
• All: 7 reference(s)