Bwnd2wk2^NMRI8/Fbn
QTL Variant Detail

Summary

• QTL variant: Bwnd2wk2^NMRI8/Fbn
• Name: body weight, NMR1 x DBA, 2 week, QTL 2; NMRI8/Fbn
• MGI ID: MGI:3497868
• QTL: Bwnd2wk2 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: NMRI8/Fbn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 2 weeks of age compared to DBA/2OlaHsd. (J:93070)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Bwnd2wk2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93070

Linkage analysis was performed on 275 animals from a (NMRI8/Fbn x DBA/2OlaHsd)F2 intercross to identify QTLs associated with post-weaning body weight and body composition. Parental strain NMRI8/Fbn is 2.5 times heavier than parental strain DBA/OlaHsd, and also exhibits increased muscle and organ weight at 6 weeks of age and 4.6 times the amount of reproductive fat of DBA/2OlaHsd. 92 microsatellite markers were used for the genome scan.

An interval on mouse Chromosome 2 from 45 cM - 50 cM showed linkage to body weight at all ages. These QTLs were designated Bwnd2wk1 (50 cM), Bwnd4wk2 (48 cM), Bwnd5wk2 (50 cM), and Bwnd6wk2 (47 cM). NMRI8/Fbn-derived alleles confer increased body weight with a dominant mode of inheritance at these loci. A second interval at the distal end of chromosome 2 around 109 cM showed linkage to body weight at 2 and 5 weeks of age. These QTLs were designated Bwnd2wk2 and Bwnd5wk3. (Suggestive linkage to body weight at 4 weeks was also observed.) NMRI8/Fbn-derived alleles confer increased body weight with a recessive mode of inheritance at Bwnd2wk2 and Bwnd5wk3.

References

• Original: J:93070 Brockmann GA, et al., QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome. 2004 Aug;15(8):593-609
• All: 1 reference(s)