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Bwnd5wk3NMRI8/Fbn
QTL Variant Detail
Summary
QTL variant: Bwnd5wk3NMRI8/Fbn
Name: body weight, NMR1 x DBA, 5 week, QTL 3; NMRI8/Fbn
MGI ID: MGI:3497894
QTL: Bwnd5wk3  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  NMRI8/Fbn
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased body weight at 5 weeks of age compared to DBA/2OlaHsd. (J:93070)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Bwnd5wk3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93070

Linkage analysis was performed on 275 animals from a (NMRI8/Fbn x DBA/2OlaHsd)F2 intercross to identify QTLs associated with post-weaning body weight and body composition. Parental strain NMRI8/Fbn is 2.5 times heavier than parental strain DBA/OlaHsd, and also exhibits increased muscle and organ weight at 6 weeks of age and 4.6 times the amount of reproductive fat of DBA/2OlaHsd. 92 microsatellite markers were used for the genome scan.

An interval on mouse Chromosome 2 from 45 cM - 50 cM showed linkage to body weight at all ages. These QTLs were designated Bwnd2wk1 (50 cM), Bwnd4wk2 (48 cM), Bwnd5wk2 (50 cM), and Bwnd6wk2 (47 cM). NMRI8/Fbn-derived alleles confer increased body weight with a dominant mode of inheritance at these loci. A second interval at the distal end of chromosome 2 around 109 cM showed linkage to body weight at 2 and 5 weeks of age. These QTLs were designated Bwnd2wk2 and Bwnd5wk3. (Suggestive linkage to body weight at 4 weeks was also observed.) NMRI8/Fbn-derived alleles confer increased body weight with a recessive mode of inheritance at Bwnd2wk2 and Bwnd5wk3.

References
Original:  J:93070 Brockmann GA, et al., QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome. 2004 Aug;15(8):593-609
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory