Irs2^tm2Mfw
Targeted Allele Detail

Summary

• Symbol: Irs2^tm2Mfw
• Name: insulin receptor substrate 2; targeted mutation 2, Morris F White
• MGI ID: MGI:3497903
• Synonyms: fIrs2, Irs2^L
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^tm2Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93415
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank the coding region with loxP sites. Transient expression of a Cre plasmid excised a floxed neo that had be included in the 5' region of the vector. (J:93415)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 37 strains or lines available

References

• Original: J:93415 Lin X, et al., Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Nov;114(7):908-16
• All: 29 reference(s)