Raf1^tm2Bacc
Targeted Allele Detail

Summary

• Symbol: Raf1^tm2Bacc
• Name: v-raf-leukemia viral oncogene 1; targeted mutation 2, Manuela Baccarini
• MGI ID: MGI:3497907
• Synonyms: c-raf-1^flox, Craf^f
• Gene: Raf1 Location: Chr6:115595530-115653596 bp, - strand Genetic Position: Chr6, 53.62 cM, cytoband C3
• Alliance: Raf1^tm2Bacc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93687
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 3 with loxP sites and to insert a floxed neo into intron 2. Transfection with Cre-expressing plasmid removed the neo. (J:93687)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Raf1^tm2Bacc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Raf1 Mutation: 117 strains or lines available

References

• Original: J:93687 Jesenberger V, et al., Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med. 2001 Feb 5;193(3):353-64
• All: 23 reference(s)