Bcl6b^tm1Tto
Targeted Allele Detail

Summary

• Symbol: Bcl6b^tm1Tto
• Name: B cell CLL/lymphoma 6, member B; targeted mutation 1, Takeshi Tokuhisa
• MGI ID: MGI:3497910
• Synonyms: BAZF^-
• Gene: Bcl6b Location: Chr11:70114954-70120624 bp, - strand Genetic Position: Chr11, 42.99 cM, cytoband B4
• Alliance: Bcl6b^tm1Tto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93656
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5, including the ATG were replaced with a neomycin resistance gene. mRNA was not detected in any tissues examined by Northern blot. (J:93656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6b Mutation: 16 strains or lines available

References

• Original: J:93656 Takamori M, et al., BAZF is required for activation of naive CD4 T cells by TCR triggering. Int Immunol. 2004 Oct;16(10):1439-49
• All: 2 reference(s)