Aimp2^{Gt(OST7994)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Aimp2^{Gt(OST7994)Lex}
• Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; gene trap OST7994, Lexicon Genetics
• MGI ID: MGI:3497919
• Synonyms: Mapk14^Gt1Skim, Mapk14^{Gt(OST7994)Lex}, p38^-
• Gene: Aimp2 Location: Chr5:143839522-143846657 bp, - strand Genetic Position: Chr5, 82.8 cM
• Alliance: Aimp2^{Gt(OST7994)Lex} page

Mutation origin

• Mutant Cell Line: OST7994
• Germline Transmission: Earliest citation of germline transmission: J:93041
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector was inserted into exon 1 of the gene. Northern and Western blot analyses demonstrated a lack of wild-type transcript and protein, respectively, in mutants. (J:93041)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST7994	CG477917 ; (MGI Seq Detail)	3' RACE	Chr5:143839767-143843562 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  22 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aimp2 Mutation: 21 strains or lines available

References

• Original: J:93041 Kim JY, et al., p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7912-6
• All: 5 reference(s)