Tg(MCL1)8Caig
Transgene Detail

Summary

• Symbol: Tg(MCL1)8Caig
• Name: transgene insertion 8, Ruth W Craig
• MGI ID: MGI:3505550
• Transgene: Tg(MCL1)8Caig Location: unknown
• Alliance: Tg(MCL1)8Caig page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MCL1)8Caig expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MCL1 (4170)

  Mcl1	(MGI:101769)

• Mutation details: The transgene contains the entire human MCL1 gene, including the endogenous MCL1 promoter. Hemizygous transgenic mice expressed human MCL1 in bone marrow, lymph node, thymus, and spleen (both B- and T-cell populations). Low levels of transgene expression were found in the kidney, small intestine, uterus, lung and liver. (J:50604)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:50604 Zhou P, et al., Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood. 1998 Nov 1;92(9):3226-39
• All: 5 reference(s)