Cnr1^tm1Ojm
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1Ojm
• Name: cannabinoid receptor 1; targeted mutation 1, Olivier J Manzoni
• MGI ID: MGI:3505551
• Synonyms: CB1^-
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1Ojm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93698
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the sequence spanning from part of the 5' UTR to the sixth transmembrane region. (J:93698)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:93698 Robbe D, et al., Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8384-8
• All: 3 reference(s)