Tg(CAG-Bgeo/ALPP)1Lbe
Transgene Detail

Summary

• Symbol: Tg(CAG-Bgeo/ALPP)1Lbe
• Name: transgene insertion 1, Corrinne Lobe
• MGI ID: MGI:3505556
• Synonyms: Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(CAG-Bgeo/ALPP)1Lbe, Z/AP, ZAP
• Transgene: Tg(CAG-Bgeo/ALPP)1Lbe Location: unknown
• Alliance: Tg(CAG-Bgeo/ALPP)1Lbe page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:93700
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the CMV enhancer/chicken beta-actin promoter, a floxed Beta-geo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit Hbb polyadenylation sequence. In transgenic mice expression of lacZ is widespread, with notable exceptions being erythrocytes, chondrocytes and adipocytes. This expression is observed throughout all embryonic and adult stages. (J:93700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Cre excision of lacZ and the neomycin resistance gene results in expression of the ALPP reporter.

References

• Original: J:93700 Lobe CG, et al., Z/AP, a double reporter for cre-mediated recombination. Dev Biol. 1999 Apr 15;208(2):281-92
• All: 143 reference(s)