Fv4^r
Spontaneous Allele Detail

Summary

• Symbol: Fv4^r
• Name: Friend virus susceptibility 4; host resistance (Friend leukemia virus)
• MGI ID: MGI:3505588
• Synonyms: Fv-4^r, Fv-4w^r
• Gene: Fv4 Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Fv4^r page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: This allele, associated with natural resistance to infection by ecotropic Friend murine leukemia virus (FLV, MuLV) and Murine sarcoma virus, was identified in several wild mouse populations in Japan, Southeast Asia and western North America. Sequencing demonstrated that the allele contains ecotropic MuLV-related proviral sequence beginning in the C-terminal end of the pol region and extending through the env region and the 3' long terminal repeat. (J:7952)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fv4 Mutation: 2 strains or lines available

References

• Original: J:93701 Suzuki S, et al., Isolation of Friend leukemia virus resistant line from non-inbred mouse colony. Jpn J Exp Med. 1975 Dec;45(6):467-71
• All: 9 reference(s)