Mmp19^tm1Amp
Targeted Allele Detail

Summary

• Symbol: Mmp19^tm1Amp
• Name: matrix metallopeptidase 19; targeted mutation 1, Alberto M Pendas
• MGI ID: MGI:3505589
• Synonyms: Mmp19^-
• Gene: Mmp19 Location: Chr10:128626779-128636693 bp, + strand Genetic Position: Chr10, 77.16 cM
• Alliance: Mmp19^tm1Amp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90802
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced a 3 kb fragment containing 1 kb of the promoter and exons 1 and 2 via homologous recombination. Northern blot analysis confirmed absence of RNA in liver, lung and ovary. (J:90802)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp19 Mutation: 20 strains or lines available

References

• Original: J:90802 Pendas AM, et al., Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol Cell Biol. 2004 Jun;24(12):5304-13
• All: 5 reference(s)