Tg(CETP)5203Tall
Transgene Detail

Summary

• Symbol: Tg(CETP)5203Tall
• Name: transgene insertion 5203, Alan Tall
• MGI ID: MGI:3505595
• Synonyms: CETP, NFR-CETP
• Transgene: Tg(CETP)5203Tall Location: unknown
• Alliance: Tg(CETP)5203Tall page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CETP)5203Tall expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	CETP (1071)

• Tg(CETP)5203Tall expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  human	CETP (1071)

• Mutation details: The transgene contains the human CETP mini gene under the control of its own promoter. The mini gene consists of 3.2 Kb of 5' flanking sequence, exons 1-2 and 13-16, and 2.0 Kb of 3' flanking sequence. (J:69181)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice on a genetic background that involves C57BL/6J and CBA/J show a marked increase in CETP mRNA in liver when mice are fed a high fat, high cholesterol diet. Less dramatic increases are observed in spleen, small intestine and adipose tissues. Elevated plasma CETP protein levels are also observed.

References

• Original: J:69181 Jiang XC, et al., Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J Clin Invest. 1992 Oct;90(4):1290-5
• All: 68 reference(s)