Tg(Pbsn-Cdc37)1Stp
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Cdc37)1Stp
• Name: transgene insertion 1, Lilia Stepanova
• MGI ID: MGI:3505712
• Synonyms: PB-CDC37.1
• Transgene: Tg(Pbsn-Cdc37)1Stp Location: unknown
• Alliance: Tg(Pbsn-Cdc37)1Stp page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-Cdc37)1Stp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cdc37 (MGI:109531)

• Mutation details: The transgene contains a rat probasin promoter, a mouse Cdc37 open reading frame, and SV40 Tag splice site/polyadenylation signal sequence. The transgenic insertion site is assumed to be on the Y chromosome as all transgenic mice are male. Transgenic mice overexpress Cdc37 in prostatic epithelia, a tissue where the endogenous Cdc37 gene product is absent or present at low levels. (J:93695)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:93695 Stepanova L, et al., Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene. 2000 Apr 27;19(18):2186-93
• All: 1 reference(s)