Tbx2^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx2^tm1Pa
• Name: T-box 2; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:3505715
• Synonyms: Tbx2^-
• Gene: Tbx2 Location: Chr11:85723441-85732774 bp, + strand Genetic Position: Chr11, 51.34 cM
• Alliance: Tbx2^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93610
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first two exons of the T-box coding sequence were deleted following the incorporation and subsequent deletion of a floxed PGK-neo-TK cassette. (J:93610)

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx2 Mutation: 29 strains or lines available

References

• Original: J:93610 Harrelson Z, et al., Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004 Oct;131(20):5041-52
• All: 5 reference(s)