Tg(Eno2CDK5R1)1Jdm
Transgene Detail

Summary

• Symbol: Tg(Eno2CDK5R1)1Jdm
• Name: transgene insertion 1, John D McNeish
• MGI ID: MGI:3505718
• Synonyms: NSE-p25 line A, P25
• Transgene: Tg(Eno2CDK5R1)1Jdm Location: unknown
• Alliance: Tg(Eno2CDK5R1)1Jdm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2CDK5R1)1Jdm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CDK5R1 (8851)

  Cdk5r1

  (MGI:101764)

• Mutation details: The transgene contains rat enolase 2, gamma neuronal (Eno2) promoter sequence and human cyclin-dependent kinase 5, regulatory subunit 1 sequence (CDK5R1) encoding the amino terminal proteolytic fragment p25. Robust expression of the transgenic fragment 25 is detected in the amygdala, thalamus/hypothalamus, cerebral cortex, and cerebellum. (J:82825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

A two-fold increase in the catalytic activity of Cdk5 is observed in transgenic mice. In contrast to wild-type control mice, brains from 4-month-old exhibit the presence of tau and neurofilament phosphoepitopes. Ultrastructurally, axonal swelling in neurons from the amygdala and spinal cord is observed. Affected neurons possess numerous, abnormally clustered mitochondria and lysosomes, with some evidence of cytoskeletal disorganization. Mice exhibit whole-body tremors at 4-9 weeks of age and enhanced open field locomotor activity.

References

• Original: J:82825 Ahlijanian MK, et al., Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2910-5
• All: 5 reference(s)