Tg(Pcp2-SCA2)11Plt
Transgene Detail

Summary

• Symbol: Tg(Pcp2-SCA2)11Plt
• Name: transgene insertion 11, Stefan M Pulst
• MGI ID: MGI:3505741
• Synonyms: Q58-11, Tg(Pcp2SCA2)11Plt
• Transgene: Tg(Pcp2-SCA2)11Plt Location: unknown
• Alliance: Tg(Pcp2-SCA2)11Plt page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-SCA2)11Plt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN2 (6311)

  Atxn2

  (MGI:1277223)

• Mutation details: The transgene contains a full length human spinocerebellar ataxia 2 (SCA2) cDNA (with a 58 CAG repeat) as well as the mouse Pcp2 (Purkinje cell protein 2) promoter, untranslated, and poly(A) sequences. Transcripts and protein product are detected in the cerebellum. (J:93869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93869 Huynh DP, et al., Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet. 2000 Sep;26(1):44-50
• All: 4 reference(s)