Nbn^tm1Md
Targeted Allele Detail

Summary

• Symbol: Nbn^tm1Md
• Name: nibrin; targeted mutation 1, Martin Digweed
• MGI ID: MGI:3505755
• Synonyms: Nbn^lox-6
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm1Md page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93598
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 6 with loxP sites and to insert a floxed neo in intron 5. Cre expression excised the floxed neo. (J:93598)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:93598 Demuth I, et al., An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet. 2004 Oct 15;13(20):2385-97
• All: 3 reference(s)