Ntrk1^tm1Tes
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Tes
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Lino Tessarollo
• MGI ID: MGI:3505767
• Synonyms: TrkA^-, TrkA^neo
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Tes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93578
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neopA was inserted into intron 11. Northern blot and RT-PCR indicated a lack of transcript in dorsal root ganglia of mutants. Upon cre-mediated recombination, expression of the gene is restored. (J:93578)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:93578 Coppola V, et al., Ablation of TrkA function in the immune system causes B cell abnormalities. Development. 2004 Oct;131(20):5185-95
• All: 4 reference(s)