Tbx1^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm1Dsr
• Name: T-box 1; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:3510038
• Synonyms: Tbx1^neo
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: This is a hypomorphic allele created by the insertion of an FRT-flanked neomycin resistance gene into intron 3, and loxP sites flanking exons 4-8, which encode the T-box region. RT-PCR from mutant embryos revealed that transcript levels were only 25% of the levels of wild-type. (J:93588)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:93588 Hu T, et al., Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502
• All: 9 reference(s)