Tbx1^tm1.1Dsr
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm1.1Dsr
• Name: T-box 1; targeted mutation 1.1, Deepak Srivastava
• MGI ID: MGI:3510040
• Synonyms: Tbx1^null
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm1.1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing of Tbx1^tm1Dsr with mice ubiquitously expressing Cre and mice expressing Flp recombinase in the germline creates this null allele in which the FRT-flanked neo and exons 4-8, which encode the T-box domain, were removed. (J:93588)

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:93588 Hu T, et al., Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502
• All: 3 reference(s)