Foxo3Gt(XAO26)Byg
Gene trapped Allele Detail
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Symbol: |
Foxo3Gt(XAO26)Byg |
Name: |
forkhead box O3; gene trap XAO26, BayGenomics |
MGI ID: |
MGI:3510105 |
Synonyms: |
FoxO3a-trap, Foxo3Gt(pGT0pfs)1Stlp, Foxo3Trap |
Gene: |
Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
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Alliance: |
Foxo3Gt(XAO26)Byg page
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Mutant Cell Line: |
XA026 |
Germline Transmission: |
Earliest citation of germline transmission:
J:93593
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
Mutation: |
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Insertion of gene trap vector
Vector: pGT0pfs
Vector Type: gene trap
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Mutation details: The BayGenomics pGT0pfs gene trap vector, containing a splice acceptor sequence upstream of a Beta-geo reporter gene, integrated approximately 5 kb downstream of the first coding exon, resulting in aberrant splicing of the transcript. Western blot analysis did not detect full-length or truncated protein in thymi.
(J:93593)
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Sequence Tags: |
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Sequence tag details (1 tag)
Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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Genome Context: |
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Genome Browser view of this mutation
12 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxo3 Mutation: |
51 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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Original: |
J:93593 Lin L, et al., Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity. 2004 Aug;21(2):203-13 |
All: |
12 reference(s) |
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