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Foxo3Gt(XAO26)Byg
Gene trapped Allele Detail
Summary
Symbol: Foxo3Gt(XAO26)Byg
Name: forkhead box O3; gene trap XAO26, BayGenomics
MGI ID: MGI:3510105
Synonyms: FoxO3a-trap, Foxo3Gt(pGT0pfs)1Stlp, Foxo3Trap
Gene: Foxo3  Location: Chr10:42057841-42152691 bp, - strand  Genetic Position: Chr10, 22.79 cM
Alliance: Foxo3Gt(XAO26)Byg page
Mutation
origin
Mutant Cell Line:  XA026
Germline Transmission:  Earliest citation of germline transmission: J:93593
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap
 
Mutation detailsThe BayGenomics pGT0pfs gene trap vector, containing a splice acceptor sequence upstream of a Beta-geo reporter gene, integrated approximately 5 kb downstream of the first coding exon, resulting in aberrant splicing of the transcript. Western blot analysis did not detect full-length or truncated protein in thymi. (J:93593)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo3 Mutation:  51 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:93593 Lin L, et al., Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity. 2004 Aug;21(2):203-13
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory