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Bwnd4wk4NMRI8/Fbn
QTL Variant Detail
Summary
QTL variant: Bwnd4wk4NMRI8/Fbn
Name: body weight, NMR1 x DBA, 4 week, QTL 4; NMRI8/Fbn
MGI ID: MGI:3510152
QTL: Bwnd4wk4  Location: unknown  Genetic Position: Chr8, Syntenic
Variant
origin
Strain of Specimen:  NMRI8/Fbn
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased body weight at 4 weeks of age compared to DBA/2OlaHsd. (J:93070)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93070

Linkage analysis was performed on 275 animals from a (NMRI8/Fbn x DBA/2OlaHsd)F2 intercross to identify QTLs associated with post-weaning body weight and body composition. Parental strain NMRI8/Fbn is 2.5 times heavier than parental strain DBA/OlaHsd, and also exhibits increased muscle and organ weight at 6 weeks of age and 4.6 times the amount of reproductive fat of DBA/2OlaHsd. 92 microsatellite markers were used for the genome scan.

An interval on mouse Chromosome 8 from 57 cM - 66 cM showed linkage to early body weight at 2, 3, and 4 weeks of age. These QTLs were designated Bwnd2wk5 (57 cM), Bwnd3wk1 (66 cM), and Bwnd4wk4 (66 cM). NMRI8/Fbn-derived alleles confer increased body weight with a dominant or additive mode of inheritance at these loci.

References
Original:  J:93070 Brockmann GA, et al., QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome. 2004 Aug;15(8):593-609
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory