Bwnd2wk7^NMRI8/Fbn
QTL Variant Detail

Summary

• QTL variant: Bwnd2wk7^NMRI8/Fbn
• Name: body weight, NMR1 x DBA, 2 week, QTL 7; NMRI8/Fbn
• MGI ID: MGI:3510214
• QTL: Bwnd2wk7 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: NMRI8/Fbn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 2 weeks of age compared to C57BL/6J. (J:93070)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93070

Linkage analysis was performed on 275 animals from a (NMRI8/Fbn x DBA/2OlaHsd)F2 intercross to identify QTLs associated with post-weaning body weight and body composition. Parental strain NMRI8/Fbn is 2.5 times heavier than parental strain DBA/OlaHsd, and also exhibits increased muscle and organ weight at 6 weeks of age and 4.6 times the amount of reproductive fat of DBA/2OlaHsd. 92 microsatellite markers were used for the genome scan.

An interval on mouse Chromosome 14 from 12 cM - 23 cM showed linkageto body weight at all ages. These QTLs were designated Bwnd3wk2 (23 cM), Bwnd4wk6 (12 cM), Bwnd5wk6 (13 cM), and Bwnd6wk5 (15 cM). (Suggestive linkage to body weight at 2 weeks of age was also observed.) NMRI8/Fbn-derived alleles confer decreased body weight with a dominant mode of inheritance at these loci. A second interval at the distal end of chromosome 14 from 49 cM - 52 cM showed linkage to body weight at 2 and 5 weeks of age. These QTLs were designated Bwnd2wk7 (52 cM), Bwnd4wk7 (49 cM), and Bwnd5wk7 (50 cM). (Suggestive linkage to body weight at 6 weeks of age was also observed.) NMRI8/Fbn-derived alleles confer increased body weight with a dominant mode of inheritance at these loci.

References

• Original: J:93070 Brockmann GA, et al., QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome. 2004 Aug;15(8):593-609
• All: 1 reference(s)