Tg(Ela1-TAg*)289Mjt
Transgene Detail

Summary

• Symbol: Tg(Ela1-TAg*)289Mjt
• Name: transgene insertion 289, Mary J Tevethia
• MGI ID: MGI:3510408
• Synonyms: T1-147
• Transgene: Tg(Ela1-TAg*)289Mjt Location: unknown
• Alliance: Tg(Ela1-TAg*)289Mjt page

Transgene origin

• Strain of Origin: (B6D2F1/J x C57BL/6)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The E1-T147 transgene was designed with a 4.3 kb rat elastase 1 (Ela1 or E1) gene upstream control region, LTR stabilizer, and SV40 late 16S splice site all upstream of the simian virus 40 large T antigen (TAg) coding sequence for amino acids 1-147 (with stop codon introduced at amino acid 148) and polyA sequence. The T1-147 transgenic mice (founder line 289) mice were established. (J:78026)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ela1-TAg*)289Mjt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78026 Tevethia MJ, et al., A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol. 1997 Nov;71(11):8157-66
• All: 3 reference(s)