Zfp385a^tm1Ber
Targeted Allele Detail

Summary

• Symbol: Zfp385a^tm1Ber
• Name: zinc finger protein 385A; targeted mutation 1, Alan Bernstein
• MGI ID: MGI:3510440
• Synonyms: Hzf^-
• Gene: Zfp385a Location: Chr15:103222322-103248520 bp, - strand Genetic Position: Chr15, 58.88 cM, cytoband F3
• Alliance: Zfp385a^tm1Ber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93829
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.5 kb fragment including exons encoding three zinc finger domains was replaced with IRES-LacZ and a neo. Northern blot demonstrated lack of transcript in mutant brains. (J:93829)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp385a Mutation: 18 strains or lines available

References

• Original: J:93829 Kimura Y, et al., Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med. 2002 Apr 1;195(7):941-52
• All: 5 reference(s)