Pbx3^tm1Mlc
Targeted Allele Detail

Summary

• Symbol: Pbx3^tm1Mlc
• Name: pre B cell leukemia homeobox 3; targeted mutation 1, Michael L Cleary
• MGI ID: MGI:3510441
• Synonyms: Pbx3^-
• Gene: Pbx3 Location: Chr2:34061469-34263154 bp, - strand Genetic Position: Chr2, 22.84 cM
• Alliance: Pbx3^tm1Mlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin resistance gene in opposite transcription orientation. The deletion created an early frame-shift mutation that caused termination of the reading frame upstream of its dimerization and DNA binding domains. Western blot indicated a lack of protein in brains of mutants. (J:93761)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pbx3 Mutation: 35 strains or lines available

References

• Original: J:93761 Rhee JW, et al., Pbx3 deficiency results in central hypoventilation. Am J Pathol. 2004 Oct;165(4):1343-50
• All: 7 reference(s)