Psen1^tm1Lpr
Targeted Allele Detail

Summary

• Symbol: Psen1^tm1Lpr
• Name: presenilin 1; targeted mutation 1, Laurent Pradier
• MGI ID: MGI:3510457
• Synonyms: PS1KI, Ps1^M233T,L235P
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm1Lpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93770
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Two point mutations were introduced into exon 7: M233T and L235P, and a neomycin resistance gene inserted into intron 6. Western blot demonstrated a normal levels of protein in mutants. (J:93770)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 48 strains or lines available

References

• Original: J:93770 Casas C, et al., Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol. 2004 Oct;165(4):1289-300
• All: 23 reference(s)