Gp1bb^tm1Ware
Targeted Allele Detail

Summary

• Symbol: Gp1bb^tm1Ware
• Name: glycoprotein Ib, beta polypeptide; targeted mutation 1, Jerry Ware
• MGI ID: MGI:3510459
• Synonyms: GP Ibbeta^Null
• Gene: Gp1bb Location: Chr16:18439069-18441153 bp, - strand Genetic Position: Chr16, 11.53 cM
• Alliance: Gp1bb^tm1Ware page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93756
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was designed to replace codons in exon 2 with a neomycin resistance gene. (J:93756)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gp1bb Mutation: 2 strains or lines available

Notes

ES cell line = DS2A.

References

• Original: J:93756 Kato K, et al., Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size. Blood. 2004 Oct 15;104(8):2339-44
• All: 1 reference(s)