Gulo^sfx-2J
Spontaneous Allele Detail

Summary

• Symbol: Gulo^sfx-2J
• Name: gulonolactone (L-) oxidase; spontaneous fracture 2 Jackson
• MGI ID: MGI:3510598
• Gene: Gulo Location: Chr14:66224235-66246656 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Gulo^sfx-2J page

Fracture site with extensive callus formation in Gulo^sfx-2J/Gulo^sfx-2J mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: RB156Bnr/Ei-Dsp^rul/GrsrJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This spontaneous mutation arose at The Jackson Laboratory in 2002. A noncomplementation test with Gulo^sfx demonstrated that this is an additional allele of Gulo.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gulo Mutation: 28 strains or lines available

Notes

The ruffled mutation in the background strain is still segregating in the RB156BNR/Ei-rul/J- Gulo^sfx-2J strain and when homozygous causes the Gulo^sfx-2J mice to have a ruffled looking coat.

The phenotype of this remutation is more severe than the original sfx mutation, suggesting a modifying gene may be present in the RB156BNR/Ei-rul/J background strain.

References

• Original: J:96441 Harris BS, et al., Spontaneous fracture 2 Jackson (sfx2J), a second mutation of the gulonolactone oxidase gene (Gulo). MGI Direct Data Submission. 2005
• All: 1 reference(s)