Tg(Thy1-APP^SL)28Lpr
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP^SL)28Lpr
• Name: transgene insertion 28, Laurent Pradier
• MGI ID: MGI:3510606
• Synonyms: Tg(Thy1-APP*Swe*Lon)28Lpr, Thy-1 APP, Thy1-APP751SL
• Transgene: Tg(Thy1-APP^SL)28Lpr Location: unknown
• Alliance: Tg(Thy1-APP^SL)28Lpr page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP^SL)28Lpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes the Swedish and London mutations.

• Mutation details: In this transgene construct, the cDNA encoding the human APP mutant bearing the Swedish (KM595/596NL) and London (V6421) mutations is under the control of the murine Thy1 promoter. Lines 26 and 28 expressed high levels of transgene. Line 28 was described. (J:86694)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86694 Blanchard V, et al., Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol. 2003 Nov;184(1):247-63
• All: 60 reference(s)