Met^tm2Kln
Targeted Allele Detail

Summary

• Symbol: Met^tm2Kln
• Name: met proto-oncogene; targeted mutation 2, Rudiger Klein
• MGI ID: MGI:3510619
• Synonyms: Met^2S
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm2Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94030
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A mutant human cDNA coding for the transmembrane and cytoplasmic domains of the receptor was inserted in-frame into mouse genomic sequences. The mutations resulted in alterations of two multifunctional tyrosinase motifs: Y1349VHVNATY1356VNV to Y1349EEINATY1356EEI. A floxed neo included in the construct was excised by crossing with Cre deleter mice. (J:94030)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Met Mutation: 83 strains or lines available

References

• Original: J:94030 Maina F, et al., Coupling Met to specific pathways results in distinct developmental outcomes. Mol Cell. 2001 Jun;7(6):1293-306
• All: 3 reference(s)