Lat2^tm1Mal
Targeted Allele Detail

Summary

• Symbol: Lat2^tm1Mal
• Name: linker for activation of T cells family, member 2; targeted mutation 1, Bernard Malissen
• MGI ID: MGI:3510698
• Synonyms: Lat2^tm1Pdra, Ntal^-
• Gene: Lat2 Location: Chr5:134628876-134643879 bp, - strand Genetic Position: Chr5, 74.7 cM
• Alliance: Lat2^tm1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93950
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-9, encoding amino acids 1-121, were replaced with a loxP site flanked neomycin resistance gene. Crossing with deleter mice Tg(CMV-cre)1Cgn removed the neo cassette. Immunoblots of BMMCs determined absence of protein expression from this allele in mutants. (J:93950)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lat2 Mutation: 19 strains or lines available

References

• Original: J:93950 Volna P, et al., Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001-13
• All: 9 reference(s)