Prdm1^tm1Nutt
Targeted Allele Detail

Summary

• Symbol: Prdm1^tm1Nutt
• Name: PR domain containing 1, with ZNF domain; targeted mutation 1, Stephen L Nutt
• MGI ID: MGI:3510704
• Synonyms: Blimp1-eGFP, Blimp1GFP, Blimp-1-mEGFP, Blmp1^gfp, Prdm1^gfp
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^tm1Nutt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93944
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector containing a splice acceptor, stop codons in all reading frames, IRES-eGFP cDNA and SV40 was inserted 3' of exon 6. Western blot showed the resulting protein was truncated, lacking the zinc finger motif domains encoded by exons 7 and 8. (J:93944)

Expression

In Mice Carrying this Mutation:

11 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 66 strains or lines available

References

• Original: J:93944 Kallies A, et al., Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med. 2004 Oct 18;200(8):967-77
• All: 109 reference(s)