Tg(ALB-cre,CMV-rtTA)#Wcyy
Transgene Detail

Summary

• Symbol: Tg(ALB-cre,CMV-rtTA)#Wcyy
• Name: transgene insertion, Winston C Y Yu
• MGI ID: MGI:3510916
• Synonyms: AlbTet-Cre
• Transgene: Tg(ALB-cre,CMV-rtTA)#Wcyy Location: unknown
• Alliance: Tg(ALB-cre,CMV-rtTA)#Wcyy page

Transgene origin

• Strain of Origin: ICR

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(ALB-cre,CMV-rtTA)#Wcyy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ALB (213)

  Alb	(MGI:87991)

• Mutation details: A modified human albumin promoter with a tet responsive element drives expression of cre recombinase. In the same vector, expression of the tetracycline silencer, rtTA, is driven by the CMV promoter. In the absence of tetracycline, cre expression is repressed. In the presence of tetracycline cre expression is seen in the liver. Four founders were generated. (J:93624)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ALB (human) Summary of all recombinase alleles driven by ALB. Alliance human ALB gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93624 Chang HS, et al., Using siRNA technique to generate transgenic animals with spatiotemporal and conditional gene knockdown. Am J Pathol. 2004 Nov;165(5):1535-41
• All: 1 reference(s)